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José Zacarías Rendón Párraga
Matías Arana

La anemia por deficiencia de hierro es un problema prevalente a nivel global que aparece en niños, adolescentes y mujeres en edad fértil, son los más afectados. La hemoglobina reticulocitaria es un nuevo biomarcador prometedor para el diagnóstico temprano. Objetivo. Evaluar la hemoglobina reticulocitaria para el diagnóstico precoz de anemia por deficiencia de hierro. Metodología. Se realizó una revisión sistemática en bases de datos biomédicas como PubMed, Scielo, Researchgate, Base, Cochrane Library y DOAJ; se incluyeron 24 estudios observacionales (2018-2023) sobre el uso de la hemoglobina reticulocitaria en el diagnóstico de anemia por deficiencia de hierro; se extrajeron datos sobre las características de los estudios, los valores de sensibilidad y especificidad de este biomarcador. Resultados. La hemoglobina reticulocitaria presentó una sensibilidad agrupada de 90% y una especificidad de 89,5% en los estudios analizados. También mostró una diferencia de medias significativa de -2,88 (IC 95%: -3,36 a -2,40) entre grupos con y sin anemia por deficiencia de hierro. Se encontró una heterogeneidad sustancial entre los resultados de los diferentes estudios (I2=95%; p<0,00001). Conclusión. La hemoglobina reticulocitaria demostró elevada sensibilidad y especificidad, así como una diferencia significativa entre grupos con y sin la condición, lo que evidencia su utilidad como prueba para la detección temprana de la anemia por deficiencia de hierro.

Iron deficiency anemia is a prevalent global health problem that appears in children, adolescents and women of childbearing age, who are the most affected. Reticulocyte hemoglobin is a promising new biomarker for early diagnosis. Objective. To evaluate reticulocyte hemoglobin for the early diagnosis of iron deficiency anemia. Methodology. A systematic review was conducted searching biomedical databases including PubMed, Scielo, Researchgate, Base, Cochrane Library and DOAJ; 24 observational studies (2018-2023) were included on the use of reticulocyte hemoglobin in the diagnosis of iron deficiency anemia; data were extracted on the characteristics of the studies and the sensitivity and specificity values of this biomarker. Results. Reticulocyte hemoglobin showed a pooled sensitivity of 90% and a specificity of 89.5% in the studies analyzed. It also showed a significant mean difference of -2.88 (95% CI: -3.36 to -2.40) between groups with and without iron deficiency anemia. Substantial heterogeneity was found among the results of the different studies (I2=95%; p<0.00001). Conclusion. Reticulocyte hemoglobin demonstrated high sensitivity and specificity, as well as a significant difference between groups with and without the condition, which shows its usefulness as a test for the early detection of iron deficiency anemia.

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Rendón Párraga, J. Z., & Arana, M. (2024). Hemoglobina reticulocitaria en el diagnóstico precoz de la anemia por deficiencia de hierro. Revista Vive, 7(19), 23 –. https://doi.org/10.33996/revistavive.v7i19.280
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Biografía del autor/a

José Zacarías Rendón Párraga, Universidad Técnica de Manabí. Portoviejo, Perú

Licenciado en Laboratorio Clínico, Universidad Estatal del Sur de Manabí. Maestrante en Biomedicina, Universidad Técnica de Manabí. Jefe de Laboratorio de Rendlab. Afiliado a la Maestría en Biomedicina de la Facultad de Posgrado, Universidad Técnica de Manabí en Portoviejo, Ecuador

Matías Arana, Centro de Estudios Infectologicos S.A. Stamboulian Servicios de Salud. Buenos Aires, Argentina

Bioquímico, Especialista en Gestión en el Laboratorio Clínico. Especialista en Hematología y Hemostasia. Jefe de Unidad: Hematología y Hemostasia en Centro de Estudios Infectologicos S.A. Stamboulian Servicios de Salud. Cuidad Autónoma de Buenos Aires, Argentina

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