Contenido principal del artículo

Jackie Patricia Martínez Peláez
Bryam Paul Ormaza Garate
Karina Fernanda Pucha Aguinsaca

La microbiota intestinal es la colección de microorganismos que habitan el sistema gastrointestinal de un ser humano. Estos microorganismos incluyen bacterias, virus, hongos y otros patógenos. La microbiota intestinal juega un papel importante en la salud general del cuerpo, ya que puede influir en el sistema inmune, la digestión y la absorción de nutrientes, y la producción de ciertas vitaminas. Objetivo. Determinar la relación entre la microbiota intestinal y enfermedades autoinmunes donde los microorganismos de la flora juegan un papel fundamental en la regulación de los diferentes mecanismos de defensa. Metodología. Se realizó una revisión sistemática, fue recopilada y clasificada la información usando el protocolo PRISMA, con la relación de la microbiota intestinal con enfermedades autoinmunes, cuyo algoritmo de búsqueda: (Relationship) and (intestinal) and (microbiota) and (autoimmune) and (diseases) entre los años 2017-2022. Finalmente, se encontraron 167 artículos. Conclusión. La microbiota intestinal puede tener una relación importante con el desarrollo y la progresión de algunas enfermedades autoinmunes, y el tratamiento con probióticos y prebióticos puede tener un efecto beneficioso en el curso de estas enfermedades, donde los microorganismos de la flora intestinal pueden desempeñar un papel crucial en la regulación del sistema inmune del cuerpo.

The intestinal microbiota is the collection of microorganisms that inhabit the gastrointestinal system of a human being. These microorganisms include bacteria, viruses, fungi and other pathogens. The gut microbiota plays an important role in the overall health of the body, as it can influence the immune system, digestion and absorption of nutrients, and the production of certain vitamins. Objective. To determine the relationship between the intestinal microbiota and autoimmune diseases where the microorganisms of the flora play a fundamental role in the regulation of the different defense mechanisms. Methodology. A systematic review was performed, information was collected and classified using the PRISMA protocol, with the relationship of intestinal microbiota with autoimmune diseases, whose search algorithm: (Relationship) and (intestinal) and (microbiota) and (autoimmune) and (diseases) between the years 2017-2022. Finally, 167 articles were found. Conclusion. Gut microbiota may have an important relationship with the development and progression of some autoimmune diseases, and treatment with probiotics and prebiotics may have a beneficial effect on the course of these diseases, where gut flora microorganisms may play a crucial role in regulating the body's immune system.

Descargas

Los datos de descargas todavía no están disponibles.

Detalles del artículo

Cómo citar
Martínez Peláez, J. P., Ormaza Garate, B. P., & Pucha Aguinsaca, K. F. (2023). Relación de la microbiota intestinal con enfermedades autoinmunes. Revista Vive, 6(16), 142–153. https://doi.org/10.33996/revistavive.v6i16.213
Sección
ARTÍCULO DE REVISIÓN
Biografía del autor/a

Jackie Patricia Martínez Peláez, Universidad Católica de Cuenca. Cuenca, Ecuador

Interno de medicina en la Universidad Católica de cuenca, Ecuador.

Bryam Paul Ormaza Garate, Universidad Católica de Cuenca. Cuenca, Ecuador

Médico General, Universidad Católica de Cuenca. Experiencia laboral como Médico Residente en Clínica Médica del Sur, Ecuador.

Karina Fernanda Pucha Aguinsaca, Universidad Católica de Cuenca. Cuenca, Ecuador

Magister en Gerencia en Salud para el Desarrollo Local, Universidad Técnica Particular de Loja. Especialista en Medicina Interna, Universidad Central del Ecuador. Especialista en Reumatología, Universidad de Sao Paulo, Brasil. Docente de la Facultad de Medicina de la Universidad Católica de Cuenca. Miembro de la Sociedad Brasilera de Reumatología, Ecuador.

Referencias

Lederberg J, MCcray AT. `Ome Sweet `Omics--A Genealogical Treasury of Words. Sci [Internet]. 2001 Apr 2 [cited 2022 Nov 23];15(7):8–8. Available from: https://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112007000500003

Opazo MC, Ortega-Rocha EM Coronado-Arrázola I, Bonifaz LC, Boudin H, Neunlist M, et al. Intestinal Microbiota Influences Non-Intestinal Related Autoimmune Diseases. Front Microbiol [Internet]. 2018 Mar 12 [cited 2022 Nov 23];9(MAR):432. Available from: /pmc/articles/PMC5857604/

Seksik P, Landman C. Understanding Microbiome Data: A Primer for Clinicians. Dig Dis [Internet]. 2015 Sep 23 [cited 2022 Nov 24];33(Suppl. 1):11–6. Available from: https://www.karger.com/Article/FullText/437034

Dwivedi M, Ansarullah, Radichev I, Kemp EH. Alteration of Immune-Mechanisms by Human Microbiota and Development and Prevention of Human Diseases. J Immunol Res [Internet]. 2017 Dec 28 [cited 2022 Nov 24];2017. Available from: https://www.hindawi.com/journals/jir/2017/6985256/

Yacoub R, Jacob A, Wlaschin J, McGregor M, Quigg RJ, Alexander JJ. Lupus: The microbiome angle. Immunobiology. 2018 Jun 1;223(6–7):460–5. DOI: 10.1016/j.imbio.2017.11.004

Antonini M, Conte M Lo, Sorini C, Falcone M. How the interplay between the commensal microbiota, gut barrier integrity, and mucosal immunity regulates brain autoimmunity? Front Immunol. 2019;10(AUG):1937. DOI: 10.3389/fimmu.2019.01937

Macpherson AJ, Martinic MM, Harris N. The functions of mucosal T cells in containing the indigenous commensal flora of the intestine. Cell Mol Life Sci C 2002 5912 [Internet]. 2002 Dec 1 [cited 2022 Nov 24];59(12):2088–96. Available from: https://link.springer.com/article/10.1007/s000180200009

Kabat AM, Srinivasan N, Maloy KJ. Modulation of immune development and function by intestinal microbiota. Trends Immunol. 2014 Nov 1;35(11):507–17. DOI: 10.1016/j.it.2014.07.010

Wu WJH, Zegarra-Ruiz DF, Diehl GE. Intestinal Microbes in Autoimmune and Inflammatory Disease. Front Immunol [Internet]. 2020 Dec 23 [cited 2022 Nov 24];11. Available from: /pmc/articles/PMC7786055/

Zhou L, Sonnenberg GF. Essential immunologic orchestrators of intestinal homeostasis. Sci Immunol [Internet]. 2018 [cited 2022 Nov 24];3(20). Available from: https://pubmed.ncbi.nlm.nih.gov/29440266/

Chisari E, Wouthuyzen-Bakker M, Friedrich AW, Parvizi J. The relation between the gut microbiome and osteoarthritis: A systematic review of literature. PLoS One [Internet]. 2021 Dec 1 [cited 2022 Nov 25];16(12). Available from: /pmc/articles/PMC8675674/

Wang Y, Wei J, Zhang W, Doherty M, Zhang Y, Xie H, et al. Gut dysbiosis in rheumatic diseases: A systematic review and meta-analysis of 92 observational studies. eBioMedicine [Internet]. 2022 Jun 1 [cited 2022 Nov 25];80. Available from: /pmc/articles/PMC9120231/

Medici Dualib P, Ogassavara J, Mattar R, Mariko Koga da Silva E, Atala Dib S, de Almeida Pititto B. Gut microbiota and gestational Diabetes Mellitus: A systematic review. Diabetes Res Clin Pract [Internet]. 2021 Oct 1 [cited 2022 Nov 25];180. Available from: https://pubmed.ncbi.nlm.nih.gov/34599971/

Mirza A, Forbes JD, Zhu F, Bernstein CN, Van Domselaar G, Graham M, et al. The multiple sclerosis gut microbiota: A systematic review. Mult Scler Relat Disord [Internet]. 2020 Jan 1 [cited 2022 Nov 25];37. Available from: http://www.msard-journal.com/article/S2211034819304079/fulltext

Melbye P, Olsson A, Hansen TH, Søndergaard HB, Bang Oturai A. Short-chain fatty acids and gut microbiota in multiple sclerosis. Acta Neurol Scand [Internet]. 2019 Mar 1 [cited 2022 Nov 25];139(3):208–19. Available from: https://pubmed.ncbi.nlm.nih.gov/30427062/

Lin P. The role of the intestinal microbiome in ocular inflammatory disease. Curr Opin Ophthalmol [Internet]. 2018 May 1 [cited 2022 Nov 25];29(3):261–6. Available from: https://pubmed.ncbi.nlm.nih.gov/29538183/

Pereira L, Monteiro R. Tailoring gut microbiota with a combination of Vitamin K and probiotics as a possible adjuvant in the treatment of rheumatic arthritis: a systematic review. Clin Nutr ESPEN [Internet]. 2022 [cited 2022 Nov 25];51. Available from: https://pubmed.ncbi.nlm.nih.gov/36184230/

Wagenaar CA, van de Put M, Bisschops M, Walrabenstein W, de Jonge CS, Herrema H, et al. The effect of dietary interventions on chronic inflammatory diseases in relation to the microbiome: A systematic review. Nutrients [Internet]. 2021 Sep 1 [cited 2022 Nov 25];13(9). Available from: /pmc/articles/PMC8464906/

Chu XJ, Cao NW, Zhou HY, Meng X, Guo B, Zhang HY, et al. The oral and gut microbiome in rheumatoid arthritis patients: a systematic review. Rheumatology (Oxford) [Internet]. 2021 Mar 1 [cited 2022 Nov 25];60(3):1054–66. Available from: https://pubmed.ncbi.nlm.nih.gov/33450018/

Castillo-Álvarez F, marzo-Sola ME. Papel de la microbiota intestinal en el desarrollo de diferentes enfermedades neurológicas. Neurología. 2022 Jul 1;37(6):492–8. Available from: https://www.sciencedirect.com/science/article/pii/S0213485319300829

Lemus HN, Warrington AE, Rodriguez M. Multiple Sclerosis: Mechanisms of Disease and Strategies for Myelin and Axonal Repair. Neurol Clin [Internet]. 2018 Feb 1 [cited 2022 Nov 25];36(1):1–11. Available from: https://pubmed.ncbi.nlm.nih.gov/29157392/

Shahi SK, Freedman SN, Mangalam AK. Gut microbiome in multiple sclerosis: The players involved and the roles they play. Gut Microbes [Internet]. 2017 Aug 2 [cited 2022 Nov 28];8(6):607–15. Available from: https://pubmed.ncbi.nlm.nih.gov/28696139/

Pröbstel AK, Baranzini SE. The Role of the Gut Microbiome in Multiple Sclerosis Risk and Progression: Towards Characterization of the “MS Microbiome” Neurotherapeutics [Internet]. 2018 Jan 1 [cited 2022 Nov 28];15(1):126–34. Available from: https://pubmed.ncbi.nlm.nih.gov/29147991/

Van den Hoek J, Boshuizen HC, Roorda LD, Tijhuis GJ, Nurmohamed MT, van den Bos GAM, et al. Mortality in patients with rheumatoid arthritis: a 15-year prospective cohort study. Rheumatol Int [Internet]. 2017 Apr 1 [cited 2022 Nov 28];37(4):487–93. Available from: https://pubmed.ncbi.nlm.nih.gov/28032180/

Listing J, Kekow J, Manger B, Burmester GR, Pattloch D, Zink A, et al. Mortality in rheumatoid arthritis: the impact of disease activity, treatment with glucocorticoids, TNF? inhibitors and rituximab. Ann Rheum Dis [Internet]. 2015 Feb 1 [cited 2022 Nov 28];74(2):415–21. Available from: https://pubmed.ncbi.nlm.nih.gov/24291654/

O’dell JR, Blakely KW, Mallek JA, Eckhoff PJ, Leff RD, Wees SJ, et al. Treatment of Early Seropositive Rheumatoid Arthritis a Two-Year, Double-Blind Comparison of Minocycline and Hydroxychloroquine. ARTHRITIS Rheum [Internet]. 2001 [cited 2022 Nov 28];44(10):2235–41. Available from: https://onlinelibrary.wiley.com/doi/10.1002/1529-0131

Xie Z, Chang C, Zhou Z. Molecular Mechanisms in Autoimmune Type 1 Diabetes: A Critical Review. Clin Rev Allergy Immunol. 2014 Oct 1;47(2):174–92. DOI: 10.1007/s12016-014-8422-2

Mejía-León ME, Calderón de la Barca AM. Diet, Microbiota and Immune System in Type 1 Diabetes Development and Evolution. Nutrients [Internet]. 2015 Nov 6 [cited 2022 Nov 28];7(11):9171–84. Available from: https://pubmed.ncbi.nlm.nih.gov/26561831/

Rewers M, Ludvigsson J. Environmental risk factors for type 1 diabetes. Lancet (London, England) [Internet]. 2016 Jun 4 [cited 2022 Nov 28];387(10035):2340–8. Available from: https://pubmed.ncbi.nlm.nih.gov/27302273/

Virtanen SM. Dietary factors in the development of type 1 diabetes. Pediatr Diabetes [Internet]. 2016 Jul 1 [cited 2022 Nov 28];17 Suppl 22:49–55. Available from: https://pubmed.ncbi.nlm.nih.gov/27411437/

Johnson BM, Gaudreau MC, Gudi R, Brown R, Gilkeson G, Vasu C. Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice. J Autoimmun. 2020 Mar 1. https://doi.org/10.1016/j.jaut.2020.102420

Zegarra-Ruiz DF, El Beidaq A, Iñiguez AJ, Lubrano Di Ricco M, Manfredo Vieira S, Ruff WE, et al. A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity. Cell Host Microbe. 2019 Jan 9;25(1):113-127.e6. Available from: https://pubmed.ncbi.nlm.nih.gov/30581114/

Sallmann S, Fiebig B, Hedrich CM, Heubner G, Gahr M. Systemischer lupus erythematodes im kindes- und jugendalter. Z Rheumatol. 2006 Nov;65(7):576–86. https://doi.org/10.1007/s00393-006-0115-7

López P, De Paz B, Rodríguez-Carrio J, Hevia A, Sánchez B, Margolles A, et al. Th17 responses and natural IgM antibodies are related to gut microbiota composition in systemic lupus erythematosus patients. Sci Rep [Internet]. 2016 Apr 5 [cited 2022 Nov 30];6. Available from: https://pubmed.ncbi.nlm.nih.gov/27044888/

Tumani MF, Pavez C, Parada A. "Microbiota, hábitos alimentarios y dieta en enfermedad inflamatoria intestinal." Revista chilena de nutrición 47.5 (2020): 822-829. https://doi.org/10.4067/s0717-75182020000500822

Sakamoto-Trujillo K, Arias-Gómez JS, Moreno-Gómez F. "Relación entre la colonización de la microbiota intestinal y el desarrollo de patologías inflamatorias intestinales. Revisión narrativa de la literatura." Salutem Scientia Spiritus 8.4 (2022): 56-63. https://revistas.javerianacali.edu.co/index.php/salutemscientiaspiritus/article/view/601

Serrano-Miranda EG. "El intestino-microbiota en los ejes reguladores del metabolismo." Pinelatinoamericana 2.3 (2022): 225-239. https://revistas.unc.edu.ar/index.php/pinelatam/article/view/38949

Astarita G, et al. "Autoinmunidad tiroidea: Mecanismos patogénicos comunes y distintivos en tiroiditis de Hashimoto y enfermedad de Graves." Revista argentina de endocrinología y metabolismo 49.3 (2012): 138-144. Available from: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-0342012000300006