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Silvana Alicia Soriano Eusebio
Ángel Ramiro Falcon Cabezas
Andrés Felipe Mercado González

El virus del papiloma humano es una infección prevalente, que puede infectar cualquier mucosa del cuerpo y causar verrugas genitales externas o condilomas genitales y cáncer de cuello uterino. El tratamiento es difícil con una alta recurrencia y persistencia de las mismas, lo que afecta mayormente a mujeres jóvenes. El objetivo del presente estudio fue realizar una comparación entre inmunomoduladores y crioterapia para el tratamiento de lesiones genitales en mujeres con VPH. Se realizó una revisión bibliográfica de la literatura científica, entre inmunomoduladores y crioterapia para el tratamiento de lesiones genitales en mujeres con VPH de los últimos 20 años, donde se identificaron publicaciones de revisiones sistemáticas y metaanálisis. Se concluyó que la elección de los inmunomoduladores al igual que la crioterapia es mejor utilizarlos cuando existe lesiones clínicas inducidas por el VPH en la región genital y perianal en mujeres, dependiendo de la cantidad, el tamaño, la gravedad, la ubicación de las verrugas y las preferencias del paciente.

Human papillomavirus is a prevalent infection, which can infect any mucosa of the body and cause external genital warts or genital warts and cervical cancer. Treatment is difficult with a high recurrence and persistence of the same, which mainly affects young women. The objective of the present study was to compare immunomodulators and cryotherapy for the treatment of genital lesions in women with HPV. A narrative bibliographic review of the scientific literature was carried out, between immunomodulators and cryotherapy for the treatment of genital lesions in women with HPV of the last 20 years, where publications of systematic reviews and meta-analyses were identified. It was concluded that the choice of immunomodulators, like cryotherapy, is better used when there are clinical lesions induced by HPV in the genital and perianal region in women, depending on the number, size, severity, location of the warts and patient preferences.

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Soriano Eusebio, S. A., Falcon Cabezas, Ángel R., & Mercado González, A. F. (2022). Comparación entre inmunomoduladores y crioterapia para el tratamiento de lesiones genitales en mujeres con VPH. Revista Vive, 5(15), 781–790. https://doi.org/10.33996/revistavive.v5i15.188
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Biografía del autor/a

Silvana Alicia Soriano Eusebio, Universidad Católica de Cuenca. Cuenca, Ecuador

Cosmetóloga, Centro Artesanal Eloisa. Dermatocosmiatra por específicos Buenos Aires Casa Mónica. Estudiante de medicina, Universidad Católica de Cuenca, Ecuador.

Ángel Ramiro Falcon Cabezas, Universidad Católica de Cuenca. Cuenca, Ecuador

Estudiante de Medicina, Universidad Católica De Cuenca, Ecuador.

Andrés Felipe Mercado González, Universidad Católica de Cuenca. Cuenca, Ecuador

Médico cirujano, Universidad de las Américas. Especialista en ginecología y obstetricia, Universidad Central de Ecuador, Ecuador.

Referencias

Dixit R, Bhavsar C, Marfatia YS. Laboratory diagnosis of human papillomavirus virus infection in female genital tract. Indian J Sex Transm Dis AIDS [Internet]. 2011 Jan [cited 2022 Jan 13];32(1):50. Available from: /pmc/articles/PMC3139291/

Pineda CE, Berry JM, Jay N, Palefsky JM, Welton ML. High-resolution anoscopy targeted surgical destruction of anal high-grade squamous intraepithelial lesions: a ten-year experience. Dis Colon Rectum [Internet]. 2008 [cited 2022 Jan 27];51(6):829–37. Available from: https://pubmed.ncbi.nlm.nih.gov/18363070/

Vender R, Bourcier M, Bhatia N, Lynde C. Therapeutic Options for External Genital Warts: https://doi.org/102310/7750201313074 [Internet]. 2019 Jan 21 [cited 2022 Jan 20];17(SUPPL 2). Available from: https://journals.sagepub.com/doi/10.2310/7750.2013.13074

Nguyen HP, Ramírez-Fort MK, Rady PL. The biology of human papillomaviruses. Curr Probl Dermatol [Internet]. 2014 [cited 2022 Jan 20];45:19–32. Available from: https://pubmed.ncbi.nlm.nih.gov/24643175/

Clinical Effectiveness Group British Association for Sexual Health and HIV. UK National Guidelines on the Management of Anogenital Warts 2015 [Internet]. 2015 [cited 2022 Jan 20]. p. 1–24. Available from: https://www.bashhguidelines.org/media/1075/uk-national-guideline-on-warts-2015-final.pdf

E Mahé, V Descamps, F Bouscarat, B Crickx. [Management of external genital warts by dermatologists: a French survey] - PubMed. Ann Dermatol Venereol [Internet]. 2002 [cited 2022 Jan 23];129(8–9):997–1002. Available from: https://pubmed.ncbi.nlm.nih.gov/12442096/

Jab?o?ska S. Traditional therapies for the treatment of condylomata acuminata (genital warts). Australas J Dermatol. 1998;

Nelson M. Gantz, Richard B. Brown, Steven L. Berk JWM. HUMAN PAPILLOMAVIRUS. In: Nelson Murray Gantz, editor. Manual of Clinical Problems in Infectious Disease. 5th ed. Philadelphia,PA: Lippincott Williams & Wilkins.; 2006. p. 158–65.

Mougin C; Dalstein V; Prétet JL; Gay C; Schaal JP; Riethmuller D. [Epidemiology of cervical papillomavirus infections. Recent knowledge]. Press Med. 2001;30(20):1017–23.

Gleidis, Yenisey, and Mir García. "Papiloma en labio inferior completamente resecado

con crioterapia. Presentación de un caso." I Jornada Virtual de Estomatología 2022. Ciego de Ávila. 2022.

Carrera R Joana Liz, Figueira F José Valentin, González Blanco Mireya. Imiquimod en el tratamiento de la infección vulvar por virus de papiloma humano. RevObstetGinecolVenez [Internet]. 2012 Dic [citado 2022 Sep 24]; 72( 4 ): 261-268. Disponible en: http://ve.scielo.org/scielo.php?script=sci_arttext&pid=S0048-77322012000400007&lng=es.

Gleason AG, González Ponce DMS, Gaspar DV. Diagnóstico y tratamiento de un papiloma solitario de lengua. Reporte de caso y revisión de la literatura. Rev Odontológica Mex. 2016 Jan 1;20(1):39–43.

Gkoulioni V, Eleftheriadou A, Yiotakis I, Ferekidou E, Chrisovergis A, Lazaris AC, et al. The Efficacy of Imiquimod on Dysplastic Lesions of the Oral Mucosa: An Experimental Model. Anticancer Res [Internet]. 2010 Jul 1 [cited 2022 Sep 24];30(7):2891–6. Available from: https://ar.iiarjournals.org/content/30/7/2891

González-Mariño MA, González-Mariño MA. Tratamiento inmediato en pacientes con cribado combinado (citología y prueba de VPH) para cáncer de cuello uterino. Revisiónnarrativa. GinecolObstet Mex [Internet]. 2019 [cited 2022 Sep 24];87(10):696–705. Available from: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0300-90412019001000696&lng=es&nrm=iso&tlng=es

Patel R V., Yanofsky VR, Goldenberg G. Genital Warts: A Comprehensive Review. J Clin Aesthet Dermatol [Internet]. 2012 Jun [cited 2022 Jan 13];5(6):25. Available from: /pmc/articles/PMC3390234/

Oriel JD. Natural history of genital warts. Br J Vener Dis [Internet]. 1971 [cited 2022 Jan 13];47(1):1. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1048137/

Mougin C; Dalstein V; Prétet JL; Gay C; Schaal JP; Riethmuller D. [Epidemiology of cervical papillomavirus infections. Recent knowledge]. Press Med. 2001;30(20):1017–23.

Von Krogh G, Lacey CJN, Gross G, Barrasso R, Schneider A. European course on HPV associated pathology: guidelines for primary care physicians for the diagnosis and management of anogenital warts. Sex Transm Infect [Internet]. 2000 [cited 2022 Jan 23];76(3):162–8. Available from: https://pubmed.ncbi.nlm.nih.gov/10961190/

Werner RN, Westfechtel L, Dressler C, Nast A. Self-administered interventions for anogenital warts in immunocompetent patients: a systematic review and meta-analysis. Sex Transm Infect [Internet]. 2017 May 1 [cited 2022 Jan 20];93(3):155–61. Available from: https://pubmed.ncbi.nlm.nih.gov/27803240/

Camargo CL de A, Belda Junior W, Fagundes LJ, Romiti R. A prospective, open, comparative study of 5% potassium hydroxide solution versus cryotherapy in the treatment of genital warts in men. An Bras Dermatol [Internet]. 2014 [cited 2022 Jan 23];89(2):236–40. Available from: https://pubmed.ncbi.nlm.nih.gov/24770498/

Gilson R, Nugent D, Werner RN, Ballesteros J, Ross J. 2019 IUSTI-Europe guideline for the management of anogenital warts. J Eur Acad Dermatology Venereol [Internet]. 2020 Aug 1 [cited 2022 Jan 20];34(8):1644–53. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.16522

(CDC). C for DC and P. Human Papillomavirus (HPV) Infection - STI Treatment Guidelines [Internet]. 2021 [cited 2022 Jan 13]. Available from: https://www.cdc.gov/std/treatment-guidelines/anogenital-warts.htm

Barton S, Wakefield V, O’mahony C, Edwards S. Effectiveness of topical and ablative therapies in treatment of anogenital warts: a systematic review and network meta-analysis. BMJ Open [Internet]. 2019 Oct 1 [cited 2022 Jan 23];9(10). Available from: /pmc/articles/PMC6830637/

Mulhem E, Pinelis S. Treatment of Nongenital Cutaneous Warts. Am Fam Physician [Internet]. 2011 Aug 1 [cited 2022 Jan 27];84(3):288–93. Available from: www.aafp.org/afp.

Nguyen HP, Doan HQ, Brunell DJ, Rady P, Tyring SK. Apoptotic Gene Expression in Sinecatechins-Treated External Genital and Perianal Warts. https://home.liebertpub.com/vim [Internet]. 2014 Dec 5 [cited 2022 Jan 23];27(10):556–8. Available from: https://www.liebertpub.com/doi/abs/10.1089/vim.2014.0081

Hanna E, Abadi R, Abbas O. Imiquimod in dermatology: an overview. Int J Dermatol [Internet]. 2016 Aug 1 [cited 2022 Jan 13];55(8):831–44. Available from: https://pubmed.ncbi.nlm.nih.gov/27387373/

Beutner KR, Spruance SL, Hougham AJ, Fox TL, Owens ML, Douglas J. Treatment of genital warts with an immune-response modifier (imiquimod). J Am Acad Dermatol [Internet]. 1998 [cited 2022 Jan 13];38(2 Pt 1):230–9. Available from: https://pubmed.ncbi.nlm.nih.gov/9486679/

Beutner KR, Spruance SL, Hougham AJ, Fox TL, Owens ML, Douglas J. Treatment of genital warts with an immune-response modifier (imiquimod). J Am Acad Dermatol [Internet]. 1998 [cited 2022 Jan 23];38(2 Pt 1):230–9. Available from: https://pubmed.ncbi.nlm.nih.gov/9486679/

Bertolotti A, Dupin N, Bouscarat F, Milpied B, Derancourt C. Cryotherapy to treat anogenital warts in nonimmunocompromised adults: Systematic review and meta-analysis. J Am Acad Dermatol [Internet]. 2017 Sep 1 [cited 2022 Feb 2];77(3):518–26. Available from: https://pubmed.ncbi.nlm.nih.gov/28651824/

Sugai S, Nishijima K, Enomoto T. Management of Condyloma Acuminata in Pregnancy: A Review. Sex Transm Dis [Internet]. 2021 Jun 1 [cited 2022 Feb 2];48(6):403–9. Available from: https://pubmed.ncbi.nlm.nih.gov/33093288/

Werner RN, Westfechtel L, Dressler C, Nast A. Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: a systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials. Sex Transm Infect [Internet]. 2017 Dec 1 [cited 2022 Feb 2];93(8):543–50. Available from: https://pubmed.ncbi.nlm.nih.gov/28637906/

Professional Advisory Board (PAB) of the Sexually Transmitted Infections Education Foundation. GUIDELINES FOR THE MANAGEMENT OF GENITAL, ANAL AND THROAT HPV INFECTION IN NEW ZEALAND. 9th ed. 2017;45. Available from: www.justthefacts.co.nz