Efecto del extracto acuoso liofilizado de corteza de Moringa oleifera sobre el perfil lipídico
Effect of the lyophilized aqueous extract of Moringa oleifera bark on the lipid profileBarra lateral del artículo
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Introducción: Las dislipidemias son un factor de riesgo cardiovascular prevalente a nivel mundial, especialmente en Latinoamérica. La Moringa oleifera, una planta con propiedades bioactivas documentadas, ofrece una potencial alternativa terapéutica. Objetivo: Evaluar el efecto del extracto acuoso liofilizado de corteza de M. oleifera sobre el perfil lipídico en adultos con dislipidemia moderada. Metodología: Se realizó un estudio cuasi-experimental, doble ciego, con grupo control (placebo, n=40) e intervención (500 mg/día del extracto, n=40) durante 12 semanas. Se midieron colesterol total (CT), LDL, HDL y triglicéridos (TG) al inicio y final. El análisis estadístico se realizó con SPSS v28 (p < 0,05). Resultados: El grupo experimental mostró una reducción significativa en CT (218,4 ± 22,3 a 185,6 ± 18,7 mg/dL; p < 0,001), LDL (138,2 ± 19,4 a 108,5 ± 16,2 mg/dL; p < 0,001) y TG (195,7 ± 31,8 a 154,3 ± 26,4 mg/dL; p < 0,001), junto con un aumento significativo de HDL (38,4 ± 6,1 a 46,9 ± 5,8 mg/dL; p < 0,001). El grupo control no presentó cambios significativos. Conclusiones: El extracto demostró un potente efecto hipolipemiante, consolidándose como una prometedora alternativa natural en el manejo de dislipidemias. Se sugiere avanzar a estudios clínicos de fase avanzada para validar estos hallazgos.
Introduction: Dyslipidemias are a prevalent cardiovascular risk factor worldwide, especially in Latin America. Moringa oleifera, a plant with documented bioactive properties, offers a potential therapeutic alternative. Objective: To evaluate the effect of the lyophilized aqueous extract of M. oleifera bark on the lipid profile in adults with moderate dyslipidemia. Methodology: A quasi-experimental, double-blind study was conducted with a control group (placebo, n=40) and an intervention group (500 mg/day of the extract, n=40) for 12 weeks. Total cholesterol (TC), LDL, HDL, and triglycerides (TG) were measured at baseline and at the end. Statistical analysis was performed with SPSS v28 (p < 0.05). Results: The experimental group showed a significant reduction in TC (218.4 ± 22.3 to 185.6 ± 18.7 mg/dL; p < 0.001), LDL (138.2 ± 19.4 to 108.5 ± 16.2 mg/dL; p < 0.001), and TG (195.7 ± 31.8 to 154.3 ± 26.4 mg/dL; p < 0.001), along with a significant increase in HDL (38.4 ± 6.1 to 46.9 ± 5.8 mg/dL; p < 0.001). The control group showed no significant changes. Conclusions: The extract demonstrated a potent hypolipidemic effect, establishing itself as a promising natural alternative in the management of dyslipidemias. Advancing to advanced-phase clinical studies is suggested to validate these findings.
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